By 1919, D.A. Russell had grown as the largest cavalry base in the nation. After WW1, it was turned into an air base. The last cavalry units posted at Russell were deactivated in 1927 and in 1930, D.A. Russell became Fort Francis E. Warren. Francis E. Warren was the then Governor of Wyoming who had won the Medal of Honor for actions taken in Mississippi in 1863. During WW2, the now Warren served as a training facility for the Quartermaster Corps and a POW camp. In 1949 it became Francis E. Warren Air Base.
During the Cold War, it became part of Strategic Air Command (SAC) and held Peacekeeper missiles. At the end of the Cold War, the 20TH Air Force Wing moved its headquarters to Warren, where it remains today. Although old Fort D.A. Russell does not exist anymore, what is preserved is the fort's historic district and museum.