Before attending Florida State College for Women, Huie attended Shorter College, now known as Shorter University, in Rome, Georgia. She went on to work as manager of WALB Radio from 1941-1953. She also founded the Easter Seals of Southern Georgia, which earned her the Woman of the Year award in 1950. Then along with two others, she also helped found the Albany Junior College, now known as Darton College, in 1963.
After this in 1965, Huie and a group of artists started the Left Bank Art Gallery on St. Simons, creating a tradition of sharing the love of art and humanities in the Golden Isles community. She then made her house into an island studio where she displayed and created all of her artwork in 1967.
The house of the gallery sits in was built in 1929, where the original paintings of Huie still permanently hang. The house was built by Fred Stoberg, and the house also holds the only functioning basement on Saint Simons Island. The Mildred Nix Huie Museum was acquired by the St. Simon's Land Trust in 2018 when they received a $4 million grant from the Anschutz Foundation. Huie's daughter Millie Wilcox recalls her mother's love for creating art.
“She began drawing when I was 4 years old and later taught abstract art and design,” Wilcox reminisced. “There are very few of her abstract paintings around — maybe one or two — but I loved the fact that she freehanded them. It was magical to me. It showed that she had a wonderful sense of humor.” 1