The Confederate Cemetery and Memorial is located about two blocks from where the prison once stood. three hundred prisoners and Union soldiers died of smallpox and were buried and a island in a attempt to prevent the disease from spreading. those who were not buried on the island were buried on a small plot of land north of Alton in a place known today as the Confederate Soldiers Cemetery.
In 1909 a permanent marker was placed commemorating these prisoners. A tablet on the shaft reads Erected by the United States to mark the burial place of 1,354 Confederate Soldiers who died here and at the Smallpox Hospital on the adjacent island while prisoners of war and whose graves cannot now be identified. A new Monument was erected listing the names of the Confederate Prisoners who died due to the out break of smallpox. The new memorial is located on the other side of the river where Abraham Lincoln and James Shields were scheduled to duel, but didn't because Shields backed out after seeing Lincoln's size.