The brewery, opened in 1852, is a National Historic Landmark District, and includes three buildings listed as National Historic Landmarks. Free public tours of the brewery are given. The tour takes visitors through the complex, and those of the legal age can enjoy two free glasses of any Anheuser-Busch product in the Hospitality Room after the tour. Tourists can see beer being made and packaged in a working part of the brewery.
The company keeps a rotation of its famous Budweiser Clydesdales at its headquarters, and visitors to the brewery can observe the Clydesdales in their exercise field and see their places in the carriage house. Some of the herd is kept at the company farm in St. Louis County. The farm, known as Grant's Farm (having been owned by former President Ulysses S. Grant at one time), is home to a menagerie of animals such as elephants, tortoises, and a variety of exotic hooved mammals. Since 2008, approximately half of the Budweiser Clydesdales are kept at the Warm Springs Ranch near Boonville Missouri.
The brewery was designated a U.S. National Historic Landmark in 1966.