Henderson's grandson, George Washington Henderson (G.W.), maintained the plantation in subsequent decades. Educated at both Ohio University and Marietta College, G.W. remained loyal to the Union as the American Civil War began. During the Wheeling Convention of 1861, he made those intentions clear. However, the rest of the family chose to remain with Virginia, some being influenced by their status as slave-holders on this very plantation. The Civil War engulfed this section of West Virginia. This is made clear by the Battle at Burning Springs in 1861, which occurred near Henderson Hall, and was the second battle to take place in what would become West Virginia two years later.
Notable visitors to Henderson Hall include Chief Justice John Marshall, Patrick Henry and John James Audubon. In addition to materials related to the history of the plantation and the region, Henderson Hall's exhibits include correspondence from Robert E. Lee and other prominent individuals. Visitors can also see ballots and materials related to the Lincoln-Douglas debates. Through the plantation's various displays of its rich history, guests have a chance to gain a unique perspective on the importance of West Virginia in the formation of the United States as it is today.